2016年，Z地富商长孙梁一凡，小名“莫莫”突发意外，血库告急，手术急需AB型熊猫血。莫莫姑姑表面上对新闻媒体宣布：决定拿出500万奖金在全国寻找熊猫血型人士前来为莫莫献血。深圳青年“耿真”为赢取500万奖金与友人驱车前往。与此同时，深圳医护工作者“苏想”也得知这一事件，力邀姐妹（另一位AB型熊猫血型）“水晶”前往义务捐血。不料途中被莫莫姑姑暗地聘请的黑社会头目“金爷”百般阻挠，目的是为了阻止苏想水晶献血，从而获得遗产继承权；耿真三人误闯入金爷给苏想设计的困局，身份败露，两帮人身陷困局，手术即将开始前，耿真凭勇气与智慧与金爷展开殊死搏斗帮助苏想逃脱金爷的控制。次日，耿真只身前往富商医院挽救莫莫，苏想误会耿真为500万奖金而去与之决裂，不料金爷等人再次出现追打报复，男女主角与反派展开激烈对决。
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