葛韵（凯瑟琳·泽塔琼斯）和Kiki（朱丽娅·罗伯茨）是一对姐妹，姐姐葛韵美艳照人，她和丈夫埃迪（约翰·库萨克）曾一起主演过多部卖座浪漫喜剧，在银幕内外都是人人羡慕的神仙眷侣，但是，他们的婚姻实际远没有公开宣扬的那么美妙。葛韵是个极端自我的被灌坏了的女明星，她无力控制自己的情绪，也不能妥善处理私人事务。妹妹Kiki性格温顺，她一直暗恋着姐夫埃迪，常常在埃迪和葛韵吵架之后耐心地陪伴他度过艰难的时刻，但Kiki很自卑，与美艳照人的姐姐葛韵相反，她自己是个肥妹，一朵壁花。为了赢得爱情，Kiki痛下决心，成功减肥。
葛韵为了处理好自己的私人事务，强迫好性子的Kiki为她服务，做她的私人助理。Kiki虽然十分不情愿，却出于种种原因，容忍了葛韵的霸道无理。这个时候，葛韵和埃迪的婚姻已经濒临破裂。他们正在合作主演一出新的浪漫喜剧，制作费高达8700万美元的《一次又一次》（Time over Time）。期间，埃迪发现葛韵与西班牙大众情人赫克特约会，两人还去埃迪与葛韵过去最喜欢的中餐厅吃饭。气急败坏的埃迪一怒之下企图用摩托车将两人撞死。他当然没有成功，还收到法庭的禁制令，不许他走近葛韵身边200尺。
葛韵和埃迪分手的消息传开了。更糟的是《一次又一次》的制作大大超支。该片的导演哈尔(克里斯多弗·沃肯)也是个脾气古怪的大腕儿，他不让任何人包括参与制作的工作人员知道电影的整体进展情况和完整情节，坚持要等到盛大的宣传发布会上才揭晓谜底。负责葛韵和埃迪宣传的公关专家李(比利·克里斯托)虽然恼火万分，却束手无策。
为了安抚记者们，李只好散布葛韵和埃迪正在复合的假消息。他组织了一个大型新闻发布会，要求葛韵和埃迪出席。Kiki也答应葛韵最后再帮她一次，在新闻发布会上协调葛韵和埃迪的关系，帮他们维护在公众面前的形象。于是，好戏开演了......
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