两千多年前，中华民族曾产生过七个大英雄。他们是：老聃、孔丘、孙武、范蠡、商鞅、吕不韦、秦始皇。他们以艰苦卓绝的个人奋斗，影响或改变过历史过程。本剧讲述的是——吕不韦一生波谲云诡的传奇故事。战国末年，群雄争霸，诸侯割据，战乱纷纷。然而，乱世待有英雄出，大商人吕不韦凭借自己的才华和财资，经过一生的艰难竞争，做成了古今中外最大的一笔生意——买卖国王！吕不韦弃商从政，执掌秦国大权十二年之外，为日后秦始皇统...
司空马来探监，告诉吕不韦秦王政杀人如割草，已经杀了二十七个替你求情的人。浩瀚星空，我就去凑这第二十八个吧，也让他秦王政杀人杀得圆满些。司空马一番结果打动了秦王政。秦王政宣布免去吕不韦死罪，贬为庶人，发配雒阳封地，永世不得在秦国为官。各国使臣纷纷来到相府，聘请吕不韦去自己的国家为相，吕不韦一一婉拒。乡…
嫪毐举兵谋反。秦王政地平了嫪毐之乱，并搜出两个孽子，当着赵姬的面活活摔死。赵姬哭得昏死过去。吕不韦赶来，拼着老命为太后求情，把所有罪过都揽到自己头上。吕不韦长跪在地抱着秦王政的脚，说大王可以杀我但不能杀你自己的母亲。秦王政被说动了，宣布大郑宫就是太后的冷宫，除了寡人，任何人不得出入。嫪毐谋反，被判。…
吕不韦这回是真病了，他非常伤感。嫪毐带着狐群狗党来到相府捣乱。并当着吕不韦的面让众门客们跟他去雍城再搞一部《嫪氏大典》。吕不韦气得险些昏死过去。乡贞大骂嫪毐，令其立即滚蛋！嫪毐愣了一会，随即滚蛋了。病榻上，吕不韦对乡贞的举动既感激又诧异。乡贞对吕不韦表示了真诚的爱意。吕不韦回忆起芸姜，实在不敢接受这…
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