《逆境游戏》是由德丰影业出品，黄祖权 执导的大型强情节、悬疑、轻喜剧、情感电视剧 。圣诞节前夕的一个雪夜，五岁的项南星跟随父母到国外度假，遭遇车祸，年幼的项南星目睹父母双亡的惨象。25年后，拥有最强大脑的项南星，已成为国际知名人工智能企业AE公司“未来之门”的项目负责人，希望把“未来之门”打造成为造福社会，改变人类进程的划时代革新。
但是，在一次意外事故中，项南星不省人事，同在车上的助手Alice死亡，而与此同时，AE公司“未来之门”项目的主核芯片不翼而飞，而项南星昏迷之前曾发送5封可疑邮件，被误认为是偷走“未来之门”主核芯片的人。年轻的心理学教授肖乐平正在为研究多年的“记忆宫殿”课题寻找资金支持，AE公司的董事长南宫秋沛委托，希望她运用自己最新的心理学理论从南星记忆里找到5封邮件，找回主核芯片的同时唤醒项南星。而肖乐平的同门师妹秋半夏，因为研究课题类似，成为AE公司死对头李枭的合作伙伴。经过一番努力，肖乐平终于借助AE公司的最新科技产品开始了唤醒项南星的工作，肖乐平发现项南星的脑部结构竟然与她的“记忆宫殿”课题不谋而合。Alice的未婚夫梁京墨主动找到肖乐平，希望肖乐平能够帮忙找出Alice之死的真相。梁京墨与项南星是发小，他不相信外界传得沸沸扬扬的“出轨论”，坚信好友和妻子不会背叛自己。在梁京墨的帮助下，肖乐平成功打破项南星的意识防御。但种种迹象表明，项南星早就认识肖乐平，在肖乐平成功破解第一封邮件之后，肖乐平意外发现所有的事情可能都是项南星提前安排好的，因为项南星就是那个一直默默帮助她的神秘人，令肖乐平没想到的是，项南星之所以这样做，都是因为两个人在孤儿院的一段经历，她曾用一只七彩风车，令少年项南星放弃了轻生的念头... ...随着调查的深入，真相逐个被击破……正面较量一触即发...
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