1942年，河南连年灾荒，难民们大规模逃荒到陕西，年仅十岁的郝玉兰跟随父亲也融入迁徙大军，在古城西安的小东门落下了脚。玉兰为生活所迫，嫁给了大她十八岁、并已经有了两个孩子的白老四，后又共同生育了五个孩子。玉兰和她的七个孩子以及小东门的河南乡亲们相濡以沫，共同渡过了几十年的风风雨雨。
玉兰看着躺在床上的梁长安想起了他小时候的事情，玉兰的一番话梁长安都听见了，他知道自己错了，他愿意让玉兰去请律师。在孙大保判刑的时候玉兰说出了梁长安不对并代他向他道歉，等律师读完梁长安的信后孙大保被判七年有期徒刑，孙大保认罪了，他的家人得到了照顾。孙大保的家人对玉兰表示感谢，是她的举动救了他们全家，她…
小王算过账后玉兰知道需要二十万左右，玉兰要将以前扣下工人的钱都发了，她去找东京借钱，随后玉兰又来到厂里向工人们道歉。玉兰亲自坐镇将工厂的这次危机化解，牡丹快要生了，她非要在家里生，不想去医院，玉兰急忙将她送往医院，吕盛赶到后知道牡丹生了一男孩儿。1994年秋，槐花从国外回到家中，她先后和国外的老公约翰和…
玉兰打电话将梁长安叫到酒楼，长安跪在她面前说自己做了对不起莲花的事情，她要动手时想到了梁长安的爷爷，他想让玉兰去劝莲花取得原谅。玉兰找到莲花后劝她要理解长安，莲花感觉他回不来了，玉兰知道长安吃的苦更多，长安从小心里一直感觉很孤独。莲花提出想到她妈那儿住几天，她一想到他和别的女人心里就膈应，等长安回去…
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