为了补贴日益高涨的手机话费，高中女生吉尔·约翰逊(卡米拉·贝尔 饰)到雇主家的山间豪宅打工，负责夜间临时照料孩子。豪宅依山傍水，内部装饰典雅豪华，其楼上楼下的空间布局更是别具匠心、蜿蜒交错，似乎每一个角落都存在着新状况出现的可能。锁好门窗、开启了防盗系统、把两个孩子哄入甜甜梦乡后，吉尔打算开始静静复习一下功课，但一个陌生的来电打破了室内的寂静，来电者既无号码显示，更不道明身份，电话那端寂静无语，起初吉尔只当是熟人之间搞的小小恶作剧，可是接连几次骚扰过后，无奈的吉尔只得报了警，希望警方能够追踪出来电的线索，警方安慰她说耐心等待一下，再多接几个电话，他们就能查出恶作剧的行为者。 陌生的来电仍在执着继续，最终电话那端传来了“留心你的小孩还在不？”的森然问候，似乎吉尔的一举一动都在这个陌生人的视线之内，惊恐万分的吉尔只得放下窗帘，关了灯光，希望黑暗可以成为最后一道安全的屏障。警方终于来电说查到了骚扰电话的线索，但结果却让吉尔大吃一惊，陌生来电居然就来自于这幢豪宅！这绝非一个善意的恶作剧，陌生人的意图也不仅仅是电话骚扰一下那么简单，他已经采取行动了，在这幢孤立无援且并不熟悉的豪宅内，吉尔必须战胜内心的恐惧，在警方到来之前，竭力为自己和孩子们夺取一线生机……
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