艾德里安-蒙克曾是旧金山警察局前途无量的侦探，他用非常规的方式破获了许多棘手案件，这些经历被传颂为警界传奇。但当妻子不幸遇害后，深受打击的蒙克患上了严重的强迫症，这种精神疾病令他对日常事物产生了反常的恐惧，他害怕微生物、人群、高度，甚至牛奶……最终，强迫症令他失去了工作，而每天的日常生活对他来说也变...成了艰巨的挑战。 这些日常挑战迫使蒙克雇佣了私人护士莎罗娜-弗莱明，她几乎要为他打理每件事，比如整理抽屉里的袜子。在莎罗娜的协助下，失去工作的阿蒙开办了私人侦探所，于是出现了女性版华生医生与神经质版福尔摩斯的奇妙组合。 不久以后莎罗娜搬回新泽西与前夫复婚，剩下蒙克一个人仍旧无法面对日常生活，更别说破案了。蒙克的恐惧在遇到娜塔丽-提戈，一个单身母亲后得到了缓解。做酒吧招待的娜塔丽的房子曾在一周内被盗两次，蒙克帮助她解决了案子。与娜塔丽母女相处得越久，蒙克回忆起与莎罗娜相处的那段特别时光。 身为私人侦探，蒙克仍用最不寻常的方法来破案。虽然不再是旧金山警察局的一员，蒙克昔日的上司利兰-斯特梅耶还是经常找他讨论案子，蒙克细致入微的观察力和过目不忘的天赋使很多疑难案件迎刃而解。利兰也是一位出色的侦探，但是他知道自己永远比不上杰出的蒙克，这令他既沮丧又抓狂。利兰的副手兰迪-迪舍一心想为成警局将来的传奇人物，他自然对蒙克感到非常不满。 蒙克就是这样一个怕黑、恐高、有洁癖、神经质的天才侦探，他能解决复杂的疑案，却无法解决自己的问题，而妻子遇害的悬案也是他心头永远的创伤。蒙克很想赢回警察的工作，但他是否管好自己的神经质，并一直保持高超的破案能力呢？
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