一九三八年秋，滇军委派身怀绝技的云南文山壮族姑娘陆小妹挑选武艺、枪法精湛的热血男儿，化装成商家马帮，从昆明运送止血疗伤奇药文山三七到武汉抗日前线。同时指派陆小妹远在武汉抗战的恋人、壮族警卫连长侬三，带领精锐分队，前往途中接应陆小妹率领的运输队。日军获取了这一情报，派特别行动队队长川村犬男，带领特别行动队紧急出动，欲抢在侬三前面，劫走三七。中共方面获悉日军行动，指示地下党员叶国恩，暗助滇军，防止三七落入日军之手，却被陆小妹误认为是日军间谍。一场各方力量大比拼的三七抢夺战在崇山峻岭之中打响，不想女匪首吴春花混水摸鱼，将价值万两黄金的三七劫走。陆小妹在战斗中拨开迷雾，获知叶国恩的真实身份，又得到叶国恩的鼎力相助，把叶国恩当成了自家人。危难时刻，侬三赶到陆小妹身边，这对决心到抗战胜利后再回文山老家完婚的恋人战地重逢，并肩作战，不想陆小妹壮烈牺牲。血与火的洗礼之中，吴春花猛然觉醒，把枪口指向日本鬼子。不同身份的中国人同仇敌忾，消灭疯狂的日军，保住了抗战奇药三七。侬三护送三七奔赴前线，叶国恩率领吴春花匪部改编的抗日部队，投入抗日洪流[2] 。
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