一场车祸使一名女子的丈夫和小舅子都陷入了昏迷。更糟糕的是，小舅子在苏醒后，竟然坚持认为自己就是哥哥，就是她的丈夫。 一宗交通意外在大雾弥漫的清晨发生，两辆小车在大桥上相撞，车内的驾驶员双双重度昏迷……一个叫杰西卡（莎拉·米歇尔·盖拉饰）的女人跟他们都有着非比寻常的关系，因为两名伤者，一个是他的丈夫，一个是他丈夫的弟弟…… 惊慌失措赶到医院的杰西卡，被医生告知两人的情况都很坏，虽然经过抢救脱离了生命危险，但却有着永远变成植物人的危险。杰西卡虽然悲痛欲绝，却不得不接受这个残酷的现实。幸好，丈夫的弟弟瑞曼（李·佩斯饰）在数月后终于先醒了过来，这使杰西卡看到了丈夫瑞恩（迈克尔·兰德斯饰）也康复如初的一线希望。不过更大的打击随之而来：瑞曼竟然对杰西卡说，他就是丈夫瑞恩。 面对这个啼笑皆非的事实，杰西卡起初认为是瑞曼伤患的后遗症作怪，于是她不停地开解和帮助他回到现实当中，但瑞曼不但没有如她所愿清醒过来，相反地却告诉了杰西卡很多只有丈夫瑞恩才知道的事情。杰西卡并不能接受这个近乎荒谬的事情，但她却不得不承认，瑞曼所说的事，的确很多都只有瑞恩才知道。面对瑞曼，杰西卡不知该如何解决这个问题，而这时候，瑞恩似乎有了复苏的迹象……
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