《永不退缩》剧情取材自真实事件，故事描述洁美（玛吉·吉伦哈尔饰）是一个弱势的单亲妈妈，平时辛勤工作，靠着一己之力希望给女儿最好的教育，但是女儿在学校并未受到应有的对待，只因为她有些微的语言障碍，老师不仅嘲笑，简直漠视她的存在。同校的女教师诺娜（维奥拉·戴维斯饰）对于教育事业拥有十足的热情，但随着教学经验的累积，讲课越趋成熟，热情却递减；诺娜心中有一个痛：她钟爱的儿子也有学习上的障碍，而整个政府的教育系统并没有办法妥善照顾她的儿子。一个是毫无背景的单亲妈妈，一个是教育系统下最基层的教师；两人都很爱自己的小孩，都认为在教育上，他们不该被牺牲。两位妈妈携手发起的勇敢行动，她们奋力对抗整个僵化的官僚体制；在“永不退缩”的信念下，最后太阳再次升起时，世界改变了吗？
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